Suggestions:

1. Try dropping Necrosis for Autobar.  I dropped Cryolysis (mage version of Necrosis) for Autobar awhile back and haven't regretted it once.

2. Drop SWStats for Recount.  Way more powerful.

3. Get rid of the little box with all the minimap icons.  In fact, get rid of all of the "attached to minimap" stuff.  95% of that can/chould go on FuBar.  Get Chinchilla for your minimap to turn off any additional buttons you don't need/want.

4. Hide your bag bar and try a fubar mod called "GarbageFu."  You can click on it to open your bags, it puts a button on your vendor frames to sell all of your "trash" with one click.  (You can define what is trash and what is not.)

5. My personal preference is to hide the text for pretty much all of the fubar mods that don't have some sort of convenient fubar display feature.  (Like QuestFu's quick display of # of quests/quests completed)

6. I would personally fadeout the main game menu bar so it only appears on mouseover. In your case, this would make a little more room for target of target frames and such.

7. I know Garreth swears by Mr. Plow, but just get ArkInventory for your bags.  It's superior in every way to every other bag mod I ahve ever seen.  You can setup custom groupings for everything, and it has a built in sorting feature that 100% obsoletes Mr. Plow . . . and then some. (Click on the bag picture in the upper left, go down to "Sorting" and pick "User Defined."  Then click all the items under "Sort Order" that you want to sort by, they will turn green and get a big check mark next to them when they're on.  You can then use the little sub menus under each sort order item to pick which sort method has the highest priority by moving them up and down the list.)